EPHA2 and breast carcinoma: To investigate the mechanistic details through which exosomal EphA2 promoted the invasiveness of breast cancer cells, full-length EphA2 and its mutants, EphA2-ΔL, EphA2-ΔS, and EphA2-S897A, were constructed into pCDNA3.1-mCherry and transfected into HEK-293T cells.