Consistently, ARIH1 overexpression resulted in an increased expression of inflammatory cytokines, including IFNγ, tumor necrosis factor-α, and T-cell chemokines C-C motif chemokine ligand 5 (CCL-5) and C-X-C motif chemokine ligand 10 (CXCL-10), as judged by quantitative reverse transcription PCR (qRT-PCR) of the whole tumor mRNA (Supplementary Fig. 10a–d). This evidence concerns the gene TNF and neoplasm.