ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: Previous findings revealed that betatrophin regulates glucose and lipid metabolism.[14] Abnormal betatrophin secretion has been associated with the development of metabolic diseases, as well as various abnormal health conditions, including obesity, type 2 diabetes mellitus,[15,16] and GDM.[17] A study also reported that plasma betatrophin levels in pregnant women are reduced with increasing gestational weeks but returned to normal levels after delivery.[18] However, there is still ambiguity as to the levels of betatrophin between GDM and normal pregnant women.