It participates in the metabolism of glucose and lipids, and is closely associated with the development of diabetes and cardiovascular diseases.[3–6] In addition, several studies have reported that betatrophin is closely associated with inflammatory factors, including high-sensitivity C-reactive protein (hs-CRP).[4] Serum betatrophin levels in GDM patients have been shown to differ, to a certain degree, compared with normal pregnant women,[7] suggesting that betatrophin could be associated with the development and progression of GDM. Here, ANGPTL8 is linked to gestational diabetes.