“Diabetes Mellitus,” a term coined from Greek language where “Diabetes” stands for “a passer through” and “Mellitus” for “sweet.”[1] Diabetes mellitus (DM) is a metabolic disorder which leads to chronic hyperglycemia, the pathogenesis for which may include defects in insulin secretion, action or both.[2] Chronic autoimmune disease is considered a dominant cause behind insulin-dependent-diabetes (IDDM) which selectively destructs insulin secreting pancreatic β-cells and is treated by insulin. This evidence concerns the gene INS and metabolic disease.