In recent years, there are more and more studies on the relationship between VDR polymorphism and the risk of AP, but the results of these studies are not consistent.[10,11] In this study, we performed a systematic review and a meta-analysis to evaluate the association between different genetic variants of VDR gene and AP, and to evaluate the association of BsmI, ApaI, TaqI, and FokI polymorphisms within different ethnic subgroups. Here, VDR is linked to alkaline phosphatase measurement.