In addition, activated p53 was demonstrated to suppress EZH2 gene expression through repression of the EZH2 gene promoter, and SPRY4 was reported to promote tumor cell proliferation by activating EZH2 [23, 24], thus, the relationship among SPRY4, MDM2 and EZH2 in SW480 cells aroused our interest. Here, TP53 is linked to neoplasm.