In addition, mature miR-1246 induced by METTL3 could activate the mitogen-activated protein kinase (MAPK) pathway by suppressing sprouty-related EVH1 domain protein 2 (SPRED2), which facilitated the invasion and distant metastasis of colorectal cancer (CRC) [35]. The gene discussed is METTL3; the disease is colorectal carcinoma.