For example, anti-tumor necrosis factor (TNF) therapies have revolutionized treatment for joint inflammation in autoimmune rheumatoid arthritis (RA) [1], while patients with intestinal inflammation due to Crohn’s disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD), also respond to anti-TNF medications [2]. This evidence concerns the gene TNF and Crohn disease.