We observed higher expression levels of PC1-associated genes, for example CXCL10, STAT1, CCL2, CCL3, NFKBIA, and GBP1, in CXCL10+ CCL2+ severe COVID-19 compared to FCN1+ cells, and higher induced expression levels of these same genes in TNF-α and IFN-γ stimulation compared to TNF-α stimulation alone (Fig. 4g). This evidence concerns the gene TNF and COVID-19.