Recent research has also identified that the synergism of TNF-α and IFN-γ can trigger inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection [52], and shown increased levels of IFN-γ, TNF-α, CXCL10, and CCL2 in the serum of severe COVID-19 patients [53]. The gene discussed is TNF; the disease is COVID-19.