Ribeiro Ribeiro et al. [33] observed the expression of TKs4, cortactin, TKs5 and MT1-MMP in odontogenic keratocyst and found that these proteins were overexpressed in this aggressive odontogenic benign lesion, suggesting the formation and participation of invadopodia in the progression of this lesion. This evidence concerns the gene SH3PXD2A and Keratocystic odontogenic tumor.