Results show that the DEGs were enriched in protein processing in endoplasmic reticulum, protein export, RNA transport, apoptosis, Alzheimer’s disease, N-Glycan biosynthesis, Valine, leucine and isoleucine degradation, TNF signaling pathway, Toxoplasmosis, p53 signaling pathway, and AGE-RACE signaling pathway in diabetic complications (Figs. 5 and 6). Here, RENBP is linked to early-onset autosomal dominant Alzheimer disease.