The KEGG pathway analysis revealed that the DEGs were significantly enriched in mineral absorption, complement coagulation cascades, rheumatoid arthritis, drug metabolism-cytochrome P450, TNF signaling pathway, inflammatory mediator regulation of TRP channels, FoxO signaling pathway, Chagas disease, cytokine-cytokine receptor interaction, and pathway in cancer (Fig. 1e). The gene discussed is TNF; the disease is rheumatoid arthritis.