Four CD19-targeted CAR-T cell therapeutics have been approved by US FDA for high-risk aggressive lymphomas, including axicabtagene ciloleucel (Axi-cel) in October 2017, tisagenlecleucel (Tisa-cel) in May 2018, brexucabtagene autoleucel in July 2020 and lisocabtagene maraleucel (Liso-cel) in February 2021 [5, 8, 9, 29, 30]. This evidence concerns the gene CD19 and lymphoma.