However, they have not been comprehensively linked to aging nor CD107+ (LAMP-1) has been directly assessed in that context and while the antigen specificity, differentiation pathways, function, and accumulation of cytotoxic CD4+ cells in aging are yet to be revealed, they may mark a stage in aging with a robust immune failure and chronic inflammation or in contrast an adaptation to the late stage of aging in supercentenarians humans [66]. This evidence concerns the gene CD4 and inflammatory response.