A recent reprint identified SNRPD1 as one of the top 10 essential ribosome binding proteins for breast cancer survival from both the genome-scale RNAi loss-of-function screens (DEMETER2) and the genome-scale CRISPR-Cas9 loss-of-function screens (CERES) [14]. The gene discussed is SNRPD1; the disease is breast carcinoma.