RB1 and neoplasm: However, a selective analysis of the potential influence of the different types of somatic alterations in TP53 and RB1 (either alone or in combination) in the tumor microenvironment of MIBC, and the potential correlation of the co-alteration of these 2 genes with genomic predictors of response to ICIs has not been performed and it could be of help to understand the good therapeutic response to ICIs in tumors with neuroendocrine markers.