However, no significant differences were seen between the proportion of RB1 HD in the TP53 truncating mutations and that of TP53 WT (OR 1.60, 95% CI 0.48–4.71, p = 0.397, Fisher’s exact test), providing a potential explanation for the lower impact of TP53 missense mutants in the cell populations of the tumor microenvironment. The gene discussed is TP53; the disease is neoplasm.