The ROC curve analyses indicated SDC1 was a valuable predicter to AKI (AUC of 0.838, cutoff of 94.12 ng/ml, sensitivity of 75%, and specificity of 79.3%), TIC (AUC of 0.700, cutoff of 92.66 ng/ml, sensitivity of 76.9%, and specificity of 71.9%) within 48 h, and 28-day mortality (AUC of 0.764, cutoff of 123.63 ng/ml, sensitivity of 75.0%, and specificity of 81.1%) (P <  0.05, respectively, Table 4, Fig. 2). This evidence concerns the gene SDC1 and acute kidney injury.