Irbesartan also increased the expression of IL-10 and inhibited the expression of TNF-α in the culture supernatants of monocyte from hypertensive patients with LVH in a concentration-dependent manner; of these groups, the 10−6 mol/L group exhibited the most significant differences (P < 0.01) (Table 4, Fig. 5). This evidence concerns the gene TNF and hypertensive disorder.