In addition, the variants of two enzymes have been shown to be associated with several vascular conditions and diseases (AGXT2: carotid atherosclerosis [7], atrial fibrillation and ischemic stroke [13], and coronary heart disease [14]; DDAH1: hypertension [15] and T2DM [16]). The gene discussed is AGXT2; the disease is atrial fibrillation.