In addition, it has been shown that high ADMA levels in plasma/serum are relevant to the exaggerated BP response to exercise [8], congestive heart failure [9], and coronary atherosclerosis [11], and the AGXT2 genotypes are associated with atrial fibrillation and ischemic stroke [13] and coronary heart disease [14]. The gene discussed is AGXT2; the disease is coronary atherosclerosis.