Additionally, we transfected CRC cells with LINC00665-specific siRNAs with or without a miR-126-5p inhibitor and found that the decrease in PAK2 and FZD3 expression induced by LINC00665 knockdown could be rescued by inhibiting miR-126-5p (n = 6, P < 0.05; Figure 6E, 6F). Here, PAK2 is linked to colorectal carcinoma.