Moreover, the methylation level of one CpG site of DCN, three CpG sites of SFRP4, one CpG site of MOXD1, one CpG site of STMN2, one CpG site of COMP, two CpG sites of LAMA2, and two CpG sites of NPY1R was significantly associated with OS of HCC patients (Figure 5B). The gene discussed is COMP; the disease is hepatocellular carcinoma.