Upregulation of CCL21 (RFS: HR = 0.69, P = 0.019; PFS: HR = 0.67, P = 0.0076), IGJ (RFS: HR = 0.63, P = 0.006; PFS: HR = 0.67, P = 0.0084), and LAMA2 (RFS: HR = 0.67, P = 0.016; PFS: HR = 0.74, P = 0.043) linked with better RFS and PFS of all HCC patients. Here, JCHAIN is linked to hepatocellular carcinoma.