The expression of DCN, CCL21, IGJ, CXCL14, FCN3, LAMA2, and NPY1R was progressively decreased from normal liver, PT, to PVTT tissues, which might promote the tumorigenesis and venous metastasis of HCC, and whose high-expression might serve as favorable prognostic biomarkers of HCC patients. This evidence concerns the gene DCN and hepatocellular carcinoma.