The expression of DCN, CCL21, IGJ, CXCL14, FCN3, LAMA2, and NPY1R was progressively decreased from normal liver, PT, to PVTT tissues, which might promote the tumorigenesis and venous metastasis of HCC, and whose high-expression might serve as favorable prognostic biomarkers of HCC patients. The gene discussed is NPY1R; the disease is hepatocellular carcinoma.