In detail, 9 CpG sites of DCN, 1 CpG site of CCL12, 2 CpG sites of IGJ, 16 CpG sites of SFRP4, 13 CpG sites of MOXD1, 11 CpG sites of CXCL14, 18 CpG sites of STMN2, 7 CpG sites of FCN3, 22 CpG sites of COMP, 33 CpG sites of LAMA2, 4 CpG sites of CPA3, and 18 CpG sites of NPY1R were found significantly differently methylated in HCC, compared with normal samples (Supplementary Table 4). This evidence concerns the gene CPA3 and hepatocellular carcinoma.