Male HCC patients with higher expression of FCN3 (HR = 0.60, P = 0.026) and NPY1R (HR = 0.53, P = 0.005) might have better OS; those patients with higher expression of DCN (HR = 0.62, P = 0.009), CCL21 (HR = 0.63, P = 0.012), IGJ (HR = 0.66, P = 0.023), FCN3 (HR = 0.67, P = 0.031), and LAMA2 (HR = 0.63, P = 0.012) might have better PFS. Here, JCHAIN is linked to hepatocellular carcinoma.