Elevated expression of IGJ (OS: HR = 0.61, P = 0.014; PFS: HR = 0.63, P = 0.021) and FCN3 (OS: HR = 0.61, P = 0.044; PFS: HR = 0.66, P = 0.037) linked with favorable OS and PFS; and high-expression of DCN (HR = 0.61, P = 0.014) and LAMA2 (HR = 0.63, P = 0.02) associated with better PFS of HCC patients without a family history of cancer (Supplementary Tables 1, 2). This evidence concerns the gene JCHAIN and cancer.