• Growth hormone/IGF-1 deficiency or insensitivity• Hypothyroidism• Hypercortisolism• Precocious puberty• Pseudohypoparathyroidism• Inherited rickets (hypocalcemic and hypophosphatemic)• Diabetes mellitus with poor control• Diabetes insipidus without treatment. The gene discussed is IGF1; the disease is hypothyroidism.