• Growth hormone/IGF-1 deficiency or insensitivity• Hypothyroidism• Hypercortisolism• Precocious puberty• Pseudohypoparathyroidism• Inherited rickets (hypocalcemic and hypophosphatemic)• Diabetes mellitus with poor control• Diabetes insipidus without treatment. This evidence concerns the gene IGF1 and Central diabetes insipidus.