EML4 and lung cancer: For instance, our patient’s PTC-derived cell line showed pAKT protein expression that remained relatively unaffected (decreased signal intensity of ~20%, not significant), in contrast to a near total 98–88% decrease of pALK and pERK expression, and in contrast to the lung cancer-derived cell line NCI-H2228 (also harboring EML4-ALK v3) that showed a decrease of ~80%.