On the other hand, it has been shown by a previous study that depletion of EML4-ALK v1 or v3 suppressed pERK and pSTAT3, but not pAKT in non-transformed mouse fibroblast cells and in the lung cancer cell line H3122 (harboring EML4-ALK v1); therefore suggesting activation of ERK and STAT3 signaling by such gene fusions but not of the PI3K-AKT pathway (Takezawa et al. 2011). This evidence concerns the gene STAT3 and lung carcinoma.