Moreover, in a murine model of chronic myeloid leukemia deletion of CXCL12 in MSCs was shown to support the expansion of leukemic stem cells and suppress normal hematopoiesis, while deletion of CXCL12in endothelial cells led to a diminished expansion of leukemic stem cells [53]. The gene discussed is CXCL12; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.