The pro-longevity effects of Klotho have been partially attributed to modulation of fibroblast growth factor 23 (FGF23), Wnt, and mTOR pathways (Hu et al., 2013; Liu et al., 2007; Zhao et al., 2015), several of which have also been a targets in sarcopenia research (Woo, 2017; Becker et al., 2015; Yoshida et al., 2019; D'Antona and Nisoli, 2010). This evidence concerns the gene FGF23 and sarcopenia.