From 2010, we started comprehensive phosphoproteome analyses of brain tissues from model mice and human patients with polyglutamine diseases (Huntington's disease and cerebellar ataxia)12 and then applied the method to AD to find several proteins whose phosphorylation changed before extracellular Aβ aggregation such as MARCKS (Myristlated Alanine‐Rich C‐kinase substrate).13 The gene discussed is MARCKS; the disease is Alzheimer disease.