We presume that these results may be related to the fact that PI3K/AKT is deeply involved in many aspects of glioma pathogenesis, and TNC regulation of glioma cell function and chemosensitivity also requires the participation of PI3K/AKT, which is presented as the modulation of PI3K/AKT signaling by TNC in glioma cells (Wang et al. 2018; Nanta et al. 2019; Ma et al. 2018). Here, TNC is linked to central nervous system cancer.