CD40LG and common variable immunodeficiency: Higher IgM levels at diagnosis of CVID, female sex [1], a phenotype of late-onset combined immunodeficiency (loCID) [20], polyclonal LPD [2, 12], and immune thrombocytopenia [13] have been associated with a higher risk in some cohorts; the latter however is not yet confirmed in the recent US registry report [12].