While previous studies had shown that ablation of Postn-expressing cells prevented fibrosis and preserved the heart function after myocardial infarction or pharmacological stress, we did not observe any change in the total extent or the composition of cardiac connective tissue in hearts with double deletion of Gata4/6 in activated fibroblasts compared to controls [19]. The gene discussed is GATA4; the disease is myocardial infarction.