In addition, mutations in VPS11 in 5 patients have been suggested as leading to infantile onset leukoencephalopathy with brain white matter abnormalities, severe motor impairment, cortical blindness, intellectual disability, and seizures, as well as in a significant reduction in myelination following extensive neuronal death in the hindbrain and midbrain in an animal model43. This evidence concerns the gene VPS11 and Intellectual disability.