Its top variant (rs9290432, P=2.4 × 10–17), associated mainly with temporal, parietal and prefrontal TC, is in an intron and eQTL of the gene PLD1. This gene codes for a phospholipid enzyme that has been shown to regulate the trafficking of the protein βAPP37, the precursor of the amyloid beta whose plaques are a critical factor in the pathogenesis of Alzheimer’s disease. Here, PLD1 is linked to early-onset autosomal dominant Alzheimer disease.