Recently, reduced levels of the RMDN3 protein (sometimes also named PTPIP51) have also been found in the temporal cortex of the brains of Alzheimer’s disease patients, suggesting that a disruption of endoplasmic reticulum-mitochondria interactions mediated by RMDN3 might be part of the neuropathological process in Alzheimer’s 46. This evidence concerns the gene RMDN3 and early-onset autosomal dominant Alzheimer disease.