IPO8 and connective tissue disorder: We also identified three new syndromic associations: (1) a connective tissue disorder resembling Loeys–Dietz syndrome (LDS) (IPO8, nine patients); (2) Alagille-like syndrome with liver cholestasis and congenital heart defects (MMP15, three patients); and (3) a multiple malformation syndrome (ZNF699, 13 patients).