CHIT1 and anterior segment dysgenesis: Lyso-sphingomyelin (a deacylated form of sphingomyelin) and chitotriosidase (secreted by activated macrophages) are both elevated in plasma of patients with ASMD (ULN 9.99 μg/mL and 181μmol/L/hr, respectively).13,20 These biomarkers were monitored to assess olipudase alfa pharmacodynamic effects.