The release of adipocytokines leads to excessive immune cell recruitment with lymphocyte predominance.12,32 Hypertrophic adipocytes increase the expression of pro-inflammatory cytokines and activate CD8+ cytotoxic T lymphocytes and CD4+ helper T cells, but not Treg lymphocytes.33 Our study demonstrated that these experimental results were consistent with clinical observations in breast cancer patients. The gene discussed is CD8A; the disease is breast cancer.