However, excluding large tumour size (>20 mm; HR, 1.47; 95% CI, 1.00–2.18; P = 0.050) and high Ki-67 LI (HR, 1.94; 95% CI, 1.22–3.07; P = 0.005), other factors were not significant in multi-variable analysis. This evidence concerns the gene MKI67 and neoplasm.