Hence, miR-4646-5p/PHD3/HIF1A-mediated upregulation of RhoA and miR-4646-5p/ABHD16A/lyso-PS stimulated activation of RhoA synergistically trigger LIMK/cofilin signaling to promote GC metastasis in vitro and in vivo. The gene discussed is CFL1; the disease is gastric cancer.