DROSHA and gastric cancer: Meanwhile, in the lung and liver metastases, the RhoA protein was upregulated in GC cells with ectopic miR-4646-5p (Drosha WT/miR-4646-5p), while declined in Drosha and miR-4646-5p doubly knocked down GC cells (Drosha KD/miR-4646-5p KD) (Fig. 7C).