RHOA and gastric cancer: Next, using the TCGA database, GPR34 and RhoA, two of key factors in the miR-4646-5p/ABHD16A/lyso-PS/GPR34/RhoA/LIMK/cofilin signaling, were elevated in GC tumors with metastasis (Supplementary Fig. S8B), which were further confirmed in our cohort of GC patient with metastases (Fig. 7D).