To further validate the role of ABHD16A in promoting gastric cancer metastasis, we generated the engineered gastric cells including GC cells with ectopic Abhd16a (Drosha WT/ABHD16A), and Abhd16a and Drosha doubly knocked down cells (Drosha KD/ABHD16A KD) (Fig. 5C, Supplementary Fig. S5A). The gene discussed is DROSHA; the disease is gastric cancer.