Next, using the TCGA database, GPR34 and RhoA, two of key factors in the miR-4646-5p/ABHD16A/lyso-PS/GPR34/RhoA/LIMK/cofilin signaling, were elevated in GC tumors with metastasis (Supplementary Fig. S8B), which were further confirmed in our cohort of GC patient with metastases (Fig. 7D). The gene discussed is LIMK1; the disease is gastric cancer.