DROSHA and gastric cancer: As expected, restoration of ABHD16A in Drosha WT gastric cancer cells markedly increased tumor cell invasion potentials, while silencing Abhd16a in Drosha-knockdown GC cells (Drosha KD/ABHD16A KD) notably decreased their cell invasion abilities (Fig. 5D, Supplementary Fig. S5B), suggesting that ABHD16A plays an essential role for GC metastasis.