Thus, these data reveal a positive feedback regulation of miR-4646-5p/PHD3/HIF1A/ABHD16A in Drosha-decreased gastric tumor cells, that is, miR-4646-5p stabilizes HIF1A by targeting PHD3 and feedback promotes expression of the host gene Abhd16a and miR-4646-5p itself. Here, ABHD16A is linked to gastric neoplasm.