Thus, as shown in Fig. 7F, RhoA triggered LIMK/cofilin signaling to promote GC metastasis is closely related with miR-4646-5p/PHD3/HIF1A regulated high expression of RhoA and lyso-PS/GPR34 depended activation of RhoA in GC cells. And the schematic diagram of pro-metastatic function of miR-4646-5p/ABHD16A/lyso-PS axis in Drosha-low expressed gastric tumor was shown in Fig. 8. The gene discussed is EGLN3; the disease is gastric cancer.