Taken together, our data provide strong evidence not only for a role of TPC2 in cancer proliferation, migration, and invasion in general but specifically a twofold role for TPC2 in melanoma development by affecting on the one hand MITF protein abundance and on the other hand melanin production independently of MITF through direct interference with tyrosinase activity in melanosomes. This evidence concerns the gene TPCN2 and melanoma.