We also observed considerable densities of regulatory T-cells (CD3+FOXP3+, median 134.53 cells/mm2) and antigen-experienced T-cells expressing PD-L1 (CD3+PD-L1+ median, 58.58 cells/mm2) and B7-H3 (CD3+B7-H3+ median, 426.26 cells/mm2), suggesting a potential T-cell–suppressive axis in this group of NSCLC. This evidence concerns the gene FOXP3 and non-small cell lung carcinoma.