The mixed pattern was characterized by the close proximity and interaction between MCs and T-cells, predominantly antigen-experienced cytotoxic T-cells expressing PD-L1 and PD-1 and other inhibitory regulators such as LAG3 and TIM3; macrophages expressing B7-H3 and B7-H4; and polymorphonuclear myeloid-derived suppressor cells, suggesting that suppressive cells actively interface with the MCs and may increase the risk of tumor recurrence in those patients. The gene discussed is LAG3; the disease is neoplasm.