Despite possible antiviral response mediated by IFN to ZIKV, other important IFN-related cytokines, as IP10 (CXCL10) levels had tendency to decrease in our analysis in both neonates with or without microcephaly, whereas concentrations of IFN-α2 displayed a tendency to decrease in CSF from microcephalic neonates and increase in those without ZIKV-associated microcephaly. Here, IFNA2 is linked to microcephaly.