We observed that the MR-Egger estimate of AF on indexed LA max was attenuated after exclusion of rs67249485 (β = 1.41, SE = 0.82, P = 9.05 × 10–2), a genetic variant located on the long arm of chromosome 4 in the proximity of the PITX2 gene. The gene discussed is PITX2; the disease is atrial fibrillation.