Some conventional methods have been suggested in this regard; A study on neuroendocrine tumors (NET) presented a framework for Ki-67 assessment of NET samples that can differentiate tumoral from non-tumoral cells (such as lymphocytes) and has furthermore classified immunopositive and immunonegative tumor cells to achieve automatic Ki-67 scoring18. This evidence concerns the gene MKI67 and neuroendocrine neoplasm.