Examination of three validation datasets from AMP-AD25,38,39 (Supplementary Results 2) revealed SERPINA5 to be significantly upregulated in AD compared to controls in the temporal cortex (Mayo-TCX: FDR = 0.00004, log2FC = 2.1), superior temporal gyrus (Mount Sinai brain bank [MSBB]-Brodmann area [BM]22: FDR = 0.095, log2FC = 1.0), and parahippocampal gyrus (MSBB-BM36: FDR = 0.0016, log2FC = 2.0). The gene discussed is SERPINA5; the disease is Alzheimer disease.