In an independent cohort (Supplementary Fig. 15), we employed digital pathology to quantify SERPINA5 immunohistochemical burden in hippocampal subsectors (CA1 and subiculum) and association cortices (temporal, parietal, and frontal regions) vulnerable to AD neuropathologic change7,13 (Fig. 5d). The gene discussed is SERPINA5; the disease is Alzheimer disease.