In TP53, phosphosites p.R249 and p.T284 co-cluster with p.R273C/H that affects 11.4% of brain lower-grade glioma (LGG), 5.3% of UCS, and 3.8% of esophageal carcinoma (ESCA); TP53 p.T155 and P.S183 co-cluster with p.R175H that affects 8.3% of rectum adenocarcinoma (READ), 6.3% of colon adenocarcinoma (COAD), 6% of ESCA, 3.7% of ovarian serous cystadenocarcinoma (OV), and 3.5% of UCS. The gene discussed is TP53; the disease is colon adenocarcinoma.