Many samples with top EGFR expression in GBM also carry mutations in the same hybrid cluster, p.A289V/T and p.R252C/P, whereas in LUAD the associated mutation is the recurrent EGFR p.L858R (4.3% of LUAD) co-clustering with phosphosites p.Y869 and p.Y891. The gene discussed is EGFR; the disease is glioblastoma.