To identify the potential biological mechanisms of JWA involved in HER2-positive breast cancer, we firstly compared with normal breast epithelium using data from the interrogated TCGA database and found that JWA was significantly downregulated in breast cancer tissues (n = 1218; Fig. 1a) (https://xenabrowser.net/datapages/). This evidence concerns the gene ARL6IP5 and breast carcinoma.