To further investigate the effect of EGFR on Foxq1-induced VM, and NPC growth and metastasis in vivo, we injected the Foxq1 overexpressing 5–8F cells into BALB/c-nude mice subcutaneously or through the tail vein, then treated them with Erlotinib, Nimotuzumab or physiological saline, respectively. This evidence concerns the gene FOXQ1 and nasopharyngeal carcinoma.