In mock-infected animals, IFN-α was unaltered (P > 0.05) and IFN-β was reduced at 24 h pbi during infection with only D39ΔcbiO1, D39Δ1098, and D39ΔproB (P < 0.05) (Fig. 5 and Fig. S2I and K). Here, IFNB1 is linked to infection.