ALB and Anorexia: It does so directly, by stimulating transcapillary albumin extravasation from the intravascular to the extravascular space,35, 36 and indirectly, by promoting increased net protein loss following the onset of an inflammation-induced catabolic state and by inducing anorexia and thereby reducing nutrient intake – this phenomenon is called stress-induced hypoalbuminemia (SIH) and is not dependent upon the individual’s nutritional status.36