There is increasing evidence that some natural AMPs like cathelicidin with strong antimicrobial and anti-inflammatory activity may be excellent therapeutic candidates for sepsis (Coorens et al., 2017; Giacometti et al., 2004; Hu et al., 2016; Murakami et al., 2009; Scott et al., 2002; Song et al., 2015; Qin et al., 2019). The gene discussed is ADSL; the disease is Sepsis.