In contrast, IFNγ release by TCR1376 (Figure 2A, B) or TCR9383B2 and TCR9383B14 engineered T cells (Figure 2—figure supplement 1A, B) was not above background when cancer cells were co-cultured without prior peptide loading, indicating that the endogenous KRASG12V protein is not recognized. The gene discussed is IFNG; the disease is cancer.