Mutations in the αSyn, E3 ubiquitin ligase Parkin, leucine-rich repeat kinase 2 (LRRK2), glucocerebrosidase (GBA), and acidic sphingomyelinase (SMPD1) genes—all known causes or risk factors for PD—have been linked to autophagy-lysosomal dysfunction, enhanced exosome biogenesis and exosomal αSyn load [68–73]. This evidence concerns the gene SMPD1 and Parkinson disease.