While significant differences are seen by two-way ANOVA between individual HNRNPs, particularly for PCBP1 (HNRNPI) and HNRNPCL3/RALYL, no significant differences are observed between all NDD and non-NDD HNRNPs (Additional File 2: Figs. S3A,B, Additional File 1: Table S5). The gene discussed is RALYL; the disease is Neurodevelopmental delay.