In hnRNPH2, missense variants cluster significantly among probands with growth delay (p = 0.01), motor delay (p = 0.001), speech delay (p = 0.006), microcephaly (p = 0.01), hypotonia (0.003), seizures (p = 0.01), and cardiac abnormalities (p = 0.02) compared to controls. This evidence concerns the gene HNRNPH2 and microcephaly.