The same group described the first tandem CAR-T cells targeting HER2 and IL13Ra2, then trivalent CAR-T cells targeting HER2, IL13Rα2 and ephrin-A2, and showed better results in preclinical models of glioblastoma compared to monovalent CAR-T cells [64, 65]. This evidence concerns the gene ERBB2 and glioblastoma.