Immune therapies which have been approved in hematologic malignancies target “ideal” antigens, namely CD19, CD20 and BCMA, for several reasons: these antigens are present on all tumors cells; the normal cells which also express these antigens are dispensable and can be eliminated without excessive “on-target, off-tumor” toxicity; these antigens are expressed on the surface and as such are easily accessible without the need for presentation through the major histocompatibility complex (MHC). The gene discussed is HLA-C; the disease is neoplasm.