However, our in silico analysis revealed a positive association of CDA experession with the EMT and the invasion status at the single cell, level revealing that CDA expression is very heterogenous even within the same tumor (Fig. 2d-e), which was confirmed by our study at the protein level in lung cancer patient tissue samples (Fig. 8, and Figure S14–15, Additional file 1). This evidence concerns the gene CDA and lung cancer.